中文介紹：

THPTA（三羥丙基三唑基甲胺）是一種水溶性、非常有效的加速配體，用于銅催化的炔烴-疊氮化物點擊化學反應（CuAAC）。除了大大提高CuAAC的速率外，THPTA還最大限度地減少了對所探測細胞或生物體生理狀態(tài)的擾動，并通過進一步降低催化劑配方中的Cu負載量，允許有效的生物偶聯(lián)與抑制細胞細胞毒性。水溶性THPTA配體允許整個反應在水中運行，進一步簡化了點擊化學。

英文介紹：

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.

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參考文獻：

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